We'll assume you're ok with this, but you can opt-out if you wish. You can choose between these temperatures based on your preference for meat doneness. Now it’s time to go over brisket cooking instructions! Try These Four Options, Simple Baking Swap: How to Use the Applesauce Egg Substitute, Here’s What to Use As a Vegetable Oil Substitute Baking. Step 4: How to make beef brisket in the oven. This brisket will, however, make the meat tender, and is sure to taste much better.The average time to cook brisket is one hour per pound of the brisket. Is it ready?