One SNP, CBS C699T, is associated with an up-regulation of sulfur metabolism, which can lead to higher levels of ammonia in the blood as well as gastrointestinal symptoms. What was your first clue? I tried looking for that but did not manage to find that on Promethease. Side Effects NAC is likely safe for adults when provided as a prescription medication. So I do think dehydration could make things worse, but I don't really think it's the only cause. I have tried to give it a go again several times, but it comes back every time. thanks for sharing! The headache last week went away after 3 days. Let me know if anyone know anything about this. what dosage are you taking, and how many times per day? after reading about the highly interesting effects of NAC on Glutamate and the regulating effects of NAC on OCD, Anxiety etc I started taking NAC daily, about 2-3 Grams per day, now i´m almost two months in and I struggling with some unexpected issues: 1.) I got a stomach ache when I upped the dosage to 2400mg. I remember /u/misteryouaresodumb mentioned an issue regarding taking high levels of NAC. I used to take it with food but now I feel like that doesn’t matter. Kapseln NON-GMO, Glutenfrei,Sojafrei, Vegetarisch,Vegan; Now Foods NAC mit 600mg N-Acetyl Cysteine, 50mcg Molybdän und 25mcg Selen pro Kapsel; N-Acetyl-Cystein (NAC) ist eine stabile Form der nicht-essentiellen Aminosäire L-Cystein ; … I have similar MTHFR mutations and have taken NAC for years with no ill effects but I only take 600mg/day so not exactly comparable. NAC did the same for me but never enough to totally demolish my anxiety. It has cleared up my post nasal drip almost completely. It seems that NAC can elevate Histamine which can cause anhedonia, irritability and as we all know allergies. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor or nurse immediately if any of the following side effects occur while taking acetylcysteine: Kinda weird, but once I realized it was temporary and only while I’m on it, it doesn’t bother me. After dosing 600mg of NAC powder I … Press J to jump to the feed. A few days after stopping it goes away. I've also heard that nac can deplete b vitamins, maybe it is that? Do you have a CBS snp too? There was a trend for a greater reduction in withdrawal symptoms and craving within the NAC condition. Any idea what snp that could be? Experience. NAC has ridiculously strong effects. Are there specific tests? I'm currently in a clinical trial -- no objections to NAC there. However I recently started taking ashwagandha and it is the icing on the cake. Two pulmonologists I've seen and my PCP have no issues with NAC, nor did the COE where I was evaluated for a lung transplant. 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